Power 2 Give (see, I just had to go back and delete "to" and replace it with "2"... sorry, squashing) works kind of like Kickstarter or Donors Choose. It lists projects that need funding in the local arts and sciences, and you can choose which ones you would like to contribute to. Or more precisely, from their website:
A project of the Arts & Science Council (ASC), power2give.org empowers you to give directly to local arts, science and history projects you are passionate about. Nonprofit organizations post projects that are in need of funding. You help bring them to life with a gift.
What I like most about this website for this holiday season is that you can purchase gift cards in $25 denominations so that your friends, employees, family, Secret Santa recipient, etc can choose the project that they want to support.
Many of the projects are also supported by matching gifts from local and national sources. Some organizations have opted to eschew matching gifts from corporations, which is also cool.
I admit that I have a wee bit of a personal bias involved in this recommendation (No I'm not going to tell you what it is. I'm a woman of mystery.), but if you're not sure which organization to support, you can't go wrong with Le Petomane Theatre Ensemble. Get those actors some damned pants!